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A Brave New World?

from the November 07, 2006 eNews issue
http://www.khouse.org (visit our website for a FREE subscription)

In 1886 the author H.G. Wells published a science-fiction novel titled The Island of Dr. Moreau. It tells the story of a mysterious island inhabited by unnatural creatures. These unfortunate beasts were the result of horrific scientific experimentation, they were created part animal and part human. The novel warns of the dangers of unchecked and irresponsible scientific research.

Animal-human hybrids were once purely the stuff of science fiction, however fiction has become reality. Scientists have created sheep that possess human hearts and livers, pigs that have been born with human blood, and a variety of other creatures whose genetic makeup has been tampered with. Biologists call these hybrid animals chimeras. They are named after a mythical Greek creature that was said to possess a lion's head, a goat's body, and a serpent's tail.

More Than a Myth

In recent years cross-species experimentation has become more widespread. Scientists in the United Kingdom have plans to place human nuclei into animal eggs in order to create stem cell lines. By inserting human genetic information into hollowed out cow eggs they hope to discover new ways of treating diseases.

Meanwhile, in the US researchers have produced mice that are susceptible to viruses usually only found in humans. Scientists at the UT South Western Medical Centre created the human-mice chimeras by implanting mice with human tissue and active stem cells, thus altering the rodent's immune system.

Earlier this year, scientists at the Salk Institute in San Diego successfully engineered mice that possess a small percentage of human brain cells. Scientists injected human embryonic stem cells into the brains of rodent fetuses, resulting in the birth of mice with both human and rodent brain cells.

Scientific research involving chimeras has invoked many questions. Does the injection of human cells into a rodent's brain effect its cognitive abilities? What are the cross-species implications? How human must a chimera become before more stringent research guidelines are applied? Are there any federal laws regulating such experiments?

The Yuck Factor


The frightening reality is that there are not currently any federal guidelines to regulate chimeric experiments. Researchers have been left alone to regulate themselves, but there seems to be no consensus within the scientific community over what is and is not considered ethical. While politicians debate the ethical and moral issues, science has continued its advance.

Moral objections to chimeric research are often dismissed by proponents as simply knee-jerk reactions based on instinctual, rather than logical, thinking. These misgivings are sometime referred to by scientists as the "yuck factor." Unfortunately, many researchers describe the "yuck factor" as though it were an obstacle to scientific discovery, instead of evidence of a troubled conscience.

Exploring these new frontiers of science and medicine without the guidance of a strong moral compass will lead us into an ethical quagmire with dangerous repercussions. Albert Einstein once said that "Science without religion is lame, religion without science is blind." Without some kind of clear guidelines, we risk adopting a form of logic that would leave us tempted not only to ponder but also to do the unthinkable.

We are embarking upon an enterprise unlike anything undertaken before. The avalanche of advances in the current biotech revolution is both exciting and frightening. The promise of new remedies and cures in many diverse fields of medicine has given new hope to those who suffer from diseases like diabetes and Parkinson's. Meanwhile science continues to outrun lawmakers. The biotech revolution has produced a host of ethical questions that have yet to be answered. These questions strike at the very heart of what it means to be human.

Related Links:

  •   Human-Mice Chimeras Produced - TUV
  •   Of Mice and Men - BBC
  •   Strategic Trends: Biotech and Global Pestilence - Koinonia House